Morphological alterations and redox changes associated with hepatic warm ischemia-reperfusion injury.
Identifieur interne : 000340 ( Main/Exploration ); précédent : 000339; suivant : 000341Morphological alterations and redox changes associated with hepatic warm ischemia-reperfusion injury.
Auteurs : Rim Jawad [Suède] ; Melroy D'Souza [Suède] ; Lisa Arodin Selenius [Suède] ; Marita Wallenberg Lundgren [Suède] ; Olof Danielsson [Suède] ; Greg Nowak [Suède] ; Mikael Björnstedt [Suède] ; Bengt Isaksson [Suède]Source :
- World journal of hepatology [ 1948-5182 ] ; 2017.
Abstract
AIM
To study the effects of warm ischemia-reperfusion (I/R) injury on hepatic morphology at the ultrastructural level and to analyze the expression of the thioredoxin (TRX) and glutaredoxin (GRX) systems.
METHODS
Eleven patients undergoing liver resection were subjected to portal triad clamping (PTC). Liver biopsies were collected at three time points; first prior to PTC (baseline), 20 min after PTC (post-ischemia) and 20 min after reperfusion (post-reperfusion). Electron microscopy and morphometry were used to study and quantify ultrastructural changes, respectively. Additionally, gene expression analysis of TRX and GRX isoforms was performed by quantitative PCR. For further validation of redox protein status, immunogold staining was performed for the isoforms GRX1 and TRX1.
RESULTS
Post-ischemia, a significant loss of the liver sinusoidal endothelial cell (LSEC) lining was observed (P = 0.0003) accompanied by a decrease of hepatocyte microvilli in the space of Disse. Hepatocellular morphology was well preserved apart from the appearance of crystalline mitochondrial inclusions in 7 out of 11 patients. Post-reperfusion biopsies had similar features as post-ischemia with the exception of signs of a reactivation of the LSECs. No changes in the expression of redox-regulatory genes could be observed at mRNA level of the isoforms of the TRX family but immunoelectron microscopy indicated a redistribution of TRX1 within the cell.
CONCLUSION
At the ultrastructural level, the major impact of hepatic warm I/R injury after PTC was borne by the LSECs with detachment and reactivation at ischemia and reperfusion, respectively. Hepatocytes morphology were well preserved. Crystalline inclusions in mitochondria were observed in the hepatocyte after ischemia.
DOI: 10.4254/wjh.v9.i34.1261
PubMed: 29290907
PubMed Central: PMC5740095
Affiliations:
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86</wicri:noRegion></affiliation></author><author><name sortKey="Lundgren, Marita Wallenberg" sort="Lundgren, Marita Wallenberg" uniqKey="Lundgren M" first="Marita Wallenberg" last="Lundgren">Marita Wallenberg Lundgren</name><affiliation wicri:level="1"><nlm:affiliation>Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm S-141 86, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm S-141 86</wicri:regionArea><wicri:noRegion>Stockholm S-141 86</wicri:noRegion></affiliation></author><author><name sortKey="Danielsson, Olof" sort="Danielsson, Olof" uniqKey="Danielsson O" first="Olof" last="Danielsson">Olof Danielsson</name><affiliation wicri:level="1"><nlm:affiliation>Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm S-141 86, Sweden.</nlm:affiliation><country 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Science, Intervention, and Technology (CLINTEC), Division of Surgery, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm S-141 86</wicri:regionArea><wicri:noRegion>Stockholm S-141 86</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:29290907</idno><idno type="pmid">29290907</idno><idno type="doi">10.4254/wjh.v9.i34.1261</idno><idno type="pmc">PMC5740095</idno><idno type="wicri:Area/Main/Corpus">000273</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000273</idno><idno type="wicri:Area/Main/Curation">000273</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000273</idno><idno type="wicri:Area/Main/Exploration">000273</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Morphological alterations and redox changes associated with hepatic warm ischemia-reperfusion injury.</title><author><name sortKey="Jawad, Rim" sort="Jawad, Rim" uniqKey="Jawad R" first="Rim" last="Jawad">Rim Jawad</name><affiliation wicri:level="1"><nlm:affiliation>Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm S-141 86, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm S-141 86</wicri:regionArea><wicri:noRegion>Stockholm S-141 86</wicri:noRegion></affiliation></author><author><name sortKey="D Souza, Melroy" sort="D Souza, Melroy" uniqKey="D Souza M" first="Melroy" last="D'Souza">Melroy D'Souza</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Science, Intervention, and Technology (CLINTEC), Division of Surgery, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm S-141 86, Sweden. melroy.dsouza@karolinska.se.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Science, Intervention, and Technology (CLINTEC), Division of Surgery, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm S-141 86</wicri:regionArea><wicri:noRegion>Stockholm S-141 86</wicri:noRegion></affiliation></author><author><name sortKey="Selenius, Lisa Arodin" sort="Selenius, Lisa Arodin" uniqKey="Selenius L" first="Lisa Arodin" last="Selenius">Lisa Arodin Selenius</name><affiliation wicri:level="1"><nlm:affiliation>Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm S-141 86, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm S-141 86</wicri:regionArea><wicri:noRegion>Stockholm S-141 86</wicri:noRegion></affiliation></author><author><name sortKey="Lundgren, Marita Wallenberg" sort="Lundgren, Marita Wallenberg" uniqKey="Lundgren M" first="Marita Wallenberg" last="Lundgren">Marita Wallenberg Lundgren</name><affiliation wicri:level="1"><nlm:affiliation>Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm S-141 86, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm S-141 86</wicri:regionArea><wicri:noRegion>Stockholm S-141 86</wicri:noRegion></affiliation></author><author><name sortKey="Danielsson, Olof" sort="Danielsson, Olof" uniqKey="Danielsson O" first="Olof" last="Danielsson">Olof Danielsson</name><affiliation wicri:level="1"><nlm:affiliation>Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm S-141 86, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm S-141 86</wicri:regionArea><wicri:noRegion>Stockholm S-141 86</wicri:noRegion></affiliation></author><author><name sortKey="Nowak, Greg" sort="Nowak, Greg" uniqKey="Nowak G" first="Greg" last="Nowak">Greg Nowak</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Science, Intervention, and Technology (CLINTEC), Division of Transplantation Surgery, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm S-141 86, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Science, Intervention, and Technology (CLINTEC), Division of Transplantation Surgery, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm S-141 86</wicri:regionArea><wicri:noRegion>Stockholm S-141 86</wicri:noRegion></affiliation></author><author><name sortKey="Bjornstedt, Mikael" sort="Bjornstedt, Mikael" uniqKey="Bjornstedt M" first="Mikael" last="Björnstedt">Mikael Björnstedt</name><affiliation wicri:level="1"><nlm:affiliation>Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm S-141 86, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm S-141 86</wicri:regionArea><wicri:noRegion>Stockholm S-141 86</wicri:noRegion></affiliation></author><author><name sortKey="Isaksson, Bengt" sort="Isaksson, Bengt" uniqKey="Isaksson B" first="Bengt" last="Isaksson">Bengt Isaksson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Science, Intervention, and Technology (CLINTEC), Division of Surgery, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm S-141 86, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Science, Intervention, and Technology (CLINTEC), Division of Surgery, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm S-141 86</wicri:regionArea><wicri:noRegion>Stockholm S-141 86</wicri:noRegion></affiliation></author></analytic><series><title level="j">World journal of hepatology</title><idno type="ISSN">1948-5182</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>AIM</b></p><p>To study the effects of warm ischemia-reperfusion (I/R) injury on hepatic morphology at the ultrastructural level and to analyze the expression of the thioredoxin (TRX) and glutaredoxin (GRX) systems.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>Eleven patients undergoing liver resection were subjected to portal triad clamping (PTC). Liver biopsies were collected at three time points; first prior to PTC (baseline), 20 min after PTC (post-ischemia) and 20 min after reperfusion (post-reperfusion). Electron microscopy and morphometry were used to study and quantify ultrastructural changes, respectively. Additionally, gene expression analysis of TRX and GRX isoforms was performed by quantitative PCR. For further validation of redox protein status, immunogold staining was performed for the isoforms GRX1 and TRX1.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Post-ischemia, a significant loss of the liver sinusoidal endothelial cell (LSEC) lining was observed (P = 0.0003) accompanied by a decrease of hepatocyte microvilli in the space of Disse. Hepatocellular morphology was well preserved apart from the appearance of crystalline mitochondrial inclusions in 7 out of 11 patients. Post-reperfusion biopsies had similar features as post-ischemia with the exception of signs of a reactivation of the LSECs. No changes in the expression of redox-regulatory genes could be observed at mRNA level of the isoforms of the TRX family but immunoelectron microscopy indicated a redistribution of TRX1 within the cell.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>At the ultrastructural level, the major impact of hepatic warm I/R injury after PTC was borne by the LSECs with detachment and reactivation at ischemia and reperfusion, respectively. Hepatocytes morphology were well preserved. Crystalline inclusions in mitochondria were observed in the hepatocyte after ischemia.</p></div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">29290907</PMID><DateRevised><Year>2020</Year><Month>10</Month><Day>01</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1948-5182</ISSN><JournalIssue CitedMedium="Print"><Volume>9</Volume><Issue>34</Issue><PubDate><Year>2017</Year><Month>Dec</Month><Day>08</Day></PubDate></JournalIssue><Title>World journal of hepatology</Title><ISOAbbreviation>World J Hepatol</ISOAbbreviation></Journal><ArticleTitle>Morphological alterations and redox changes associated with hepatic warm ischemia-reperfusion injury.</ArticleTitle><Pagination><MedlinePgn>1261-1269</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.4254/wjh.v9.i34.1261</ELocationID><Abstract><AbstractText Label="AIM" NlmCategory="OBJECTIVE">To study the effects of warm ischemia-reperfusion (I/R) injury on hepatic morphology at the ultrastructural level and to analyze the expression of the thioredoxin (TRX) and glutaredoxin (GRX) systems.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Eleven patients undergoing liver resection were subjected to portal triad clamping (PTC). Liver biopsies were collected at three time points; first prior to PTC (baseline), 20 min after PTC (post-ischemia) and 20 min after reperfusion (post-reperfusion). Electron microscopy and morphometry were used to study and quantify ultrastructural changes, respectively. Additionally, gene expression analysis of TRX and GRX isoforms was performed by quantitative PCR. For further validation of redox protein status, immunogold staining was performed for the isoforms GRX1 and TRX1.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Post-ischemia, a significant loss of the liver sinusoidal endothelial cell (LSEC) lining was observed (P = 0.0003) accompanied by a decrease of hepatocyte microvilli in the space of Disse. Hepatocellular morphology was well preserved apart from the appearance of crystalline mitochondrial inclusions in 7 out of 11 patients. Post-reperfusion biopsies had similar features as post-ischemia with the exception of signs of a reactivation of the LSECs. No changes in the expression of redox-regulatory genes could be observed at mRNA level of the isoforms of the TRX family but immunoelectron microscopy indicated a redistribution of TRX1 within the cell.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">At the ultrastructural level, the major impact of hepatic warm I/R injury after PTC was borne by the LSECs with detachment and reactivation at ischemia and reperfusion, respectively. Hepatocytes morphology were well preserved. Crystalline inclusions in mitochondria were observed in the hepatocyte after ischemia.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Jawad</LastName><ForeName>Rim</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm S-141 86, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>D'souza</LastName><ForeName>Melroy</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Clinical Science, Intervention, and Technology (CLINTEC), Division of Surgery, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm S-141 86, Sweden. melroy.dsouza@karolinska.se.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Selenius</LastName><ForeName>Lisa Arodin</ForeName><Initials>LA</Initials><AffiliationInfo><Affiliation>Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm S-141 86, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lundgren</LastName><ForeName>Marita Wallenberg</ForeName><Initials>MW</Initials><AffiliationInfo><Affiliation>Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm S-141 86, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Danielsson</LastName><ForeName>Olof</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm S-141 86, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nowak</LastName><ForeName>Greg</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Clinical Science, Intervention, and Technology (CLINTEC), Division of Transplantation Surgery, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm S-141 86, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Björnstedt</LastName><ForeName>Mikael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm S-141 86, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Isaksson</LastName><ForeName>Bengt</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Clinical Science, Intervention, and Technology (CLINTEC), Division of Surgery, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm S-141 86, Sweden.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>World J Hepatol</MedlineTA><NlmUniqueID>101532469</NlmUniqueID></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Electron microscopy</Keyword><Keyword MajorTopicYN="N">Glutaredoxins</Keyword><Keyword MajorTopicYN="N">Hepatic ischemia-reperfusion injury</Keyword><Keyword MajorTopicYN="N">Ischemia reperfusion injury</Keyword><Keyword MajorTopicYN="N">Oxidative stress</Keyword><Keyword MajorTopicYN="N">Portal triad clamping</Keyword><Keyword MajorTopicYN="N">Thioredoxins</Keyword><Keyword MajorTopicYN="N">Warm ischemia-reperfusion injury</Keyword></KeywordList><CoiStatement>Conflict-of-interest statement: No conflict of interest exists.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>05</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2017</Year><Month>08</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>10</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>1</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>1</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2018</Year><Month>1</Month><Day>2</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29290907</ArticleId><ArticleId IdType="doi">10.4254/wjh.v9.i34.1261</ArticleId><ArticleId IdType="pmc">PMC5740095</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Am J Pathol. 1994 Dec;145(6):1421-31</Citation><ArticleIdList><ArticleId IdType="pubmed">7992845</ArticleId></ArticleIdList></Reference><Reference><Citation>J Cell Biol. 1969 Dec;43(3):448-55</Citation><ArticleIdList><ArticleId IdType="pubmed">5351401</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochem Biophys Res Commun. 1997 Jul 18;236(2):313-22</Citation><ArticleIdList><ArticleId IdType="pubmed">9240432</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochim Biophys Acta. 2008 Nov;1780(11):1304-17</Citation><ArticleIdList><ArticleId IdType="pubmed">18621099</ArticleId></ArticleIdList></Reference><Reference><Citation>Ann Surg. 2003 Jun;237(6):860-9; discussion 869-70</Citation><ArticleIdList><ArticleId IdType="pubmed">12796583</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biomed Biotechnol. 2012;2012:298657</Citation><ArticleIdList><ArticleId IdType="pubmed">22649277</ArticleId></ArticleIdList></Reference><Reference><Citation>Transplantation. 1989 Aug;48(2):179-88</Citation><ArticleIdList><ArticleId IdType="pubmed">2667203</ArticleId></ArticleIdList></Reference><Reference><Citation>Liver Transpl Surg. 1996 Nov;2(6):461-7</Citation><ArticleIdList><ArticleId IdType="pubmed">9346693</ArticleId></ArticleIdList></Reference><Reference><Citation>Br J Surg. 2008 Apr;95(4):424-32</Citation><ArticleIdList><ArticleId IdType="pubmed">18314921</ArticleId></ArticleIdList></Reference><Reference><Citation>Transplantation. 1999 Apr 27;67(8):1099-105</Citation><ArticleIdList><ArticleId IdType="pubmed">10232558</ArticleId></ArticleIdList></Reference><Reference><Citation>Transplantation. 1991 Jun;51(6):1176-83</Citation><ArticleIdList><ArticleId IdType="pubmed">2048194</ArticleId></ArticleIdList></Reference><Reference><Citation>Hepatology. 1991 Jun;13(6):1173-80</Citation><ArticleIdList><ArticleId IdType="pubmed">2050331</ArticleId></ArticleIdList></Reference><Reference><Citation>Acta Pharmacol Sin. 2006 Mar;27(3):259-72</Citation><ArticleIdList><ArticleId IdType="pubmed">16490160</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2000 May 26;275(21):16023-9</Citation><ArticleIdList><ArticleId IdType="pubmed">10821856</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 1999 Jul 1;400(6739):83-5</Citation><ArticleIdList><ArticleId IdType="pubmed">10403254</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2002 Nov 22;277(47):44765-71</Citation><ArticleIdList><ArticleId IdType="pubmed">12235164</ArticleId></ArticleIdList></Reference><Reference><Citation>Arch Surg. 1991 Jun;126(6):767-72</Citation><ArticleIdList><ArticleId IdType="pubmed">2039366</ArticleId></ArticleIdList></Reference><Reference><Citation>Free Radic Biol Med. 2000 Mar 15;28(6):846-53</Citation><ArticleIdList><ArticleId IdType="pubmed">10802214</ArticleId></ArticleIdList></Reference><Reference><Citation>J Hepatol. 2013 Nov;59(5):1094-106</Citation><ArticleIdList><ArticleId IdType="pubmed">23811302</ArticleId></ArticleIdList></Reference><Reference><Citation>Hepatobiliary Pancreat Dis Int. 2002 May;1(2):249-57</Citation><ArticleIdList><ArticleId IdType="pubmed">14612278</ArticleId></ArticleIdList></Reference><Reference><Citation>J Hepatol. 1999 Sep;31(3):430-4</Citation><ArticleIdList><ArticleId IdType="pubmed">10488700</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Physiol. 1999 Jan;276(1 Pt 1):G1-6</Citation><ArticleIdList><ArticleId IdType="pubmed">9886971</ArticleId></ArticleIdList></Reference><Reference><Citation>Oxid Med Cell Longev. 2014;2014:906965</Citation><ArticleIdList><ArticleId IdType="pubmed">24799983</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Surg Pathol. 1995 Dec;19(12):1409-17</Citation><ArticleIdList><ArticleId IdType="pubmed">7503362</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3633-8</Citation><ArticleIdList><ArticleId IdType="pubmed">9108029</ArticleId></ArticleIdList></Reference><Reference><Citation>Transplant Rev (Orlando). 2012 Apr;26(2):103-14</Citation><ArticleIdList><ArticleId IdType="pubmed">22459037</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Gastroenterol Hepatol. 2013 Feb;10(2):79-89</Citation><ArticleIdList><ArticleId IdType="pubmed">23229329</ArticleId></ArticleIdList></Reference><Reference><Citation>J Gastrointest Surg. 2004 Sep-Oct;8(6):695-700</Citation><ArticleIdList><ArticleId IdType="pubmed">15358330</ArticleId></ArticleIdList></Reference><Reference><Citation>Arch Biochem Biophys. 1994 Jan;308(1):1-7</Citation><ArticleIdList><ArticleId IdType="pubmed">8311441</ArticleId></ArticleIdList></Reference><Reference><Citation>Gastroenterology. 2001 Apr;120(5):1183-92</Citation><ArticleIdList><ArticleId IdType="pubmed">11266382</ArticleId></ArticleIdList></Reference><Reference><Citation>Br J Surg. 2003 Feb;90(2):183-9</Citation><ArticleIdList><ArticleId IdType="pubmed">12555294</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Immunopathol Pharmacol. 2014 Apr-Jun;27(2):169-83</Citation><ArticleIdList><ArticleId IdType="pubmed">25004829</ArticleId></ArticleIdList></Reference><Reference><Citation>Antioxid Redox Signal. 2007 Jan;9(1):25-47</Citation><ArticleIdList><ArticleId IdType="pubmed">17115886</ArticleId></ArticleIdList></Reference><Reference><Citation>Hepatology. 2004 May;39(5):1423-9</Citation><ArticleIdList><ArticleId IdType="pubmed">15122772</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Pharm Des. 2006;12(23):2875-90</Citation><ArticleIdList><ArticleId IdType="pubmed">16918418</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 1992 Dec 5;267(34):24161-4</Citation><ArticleIdList><ArticleId IdType="pubmed">1332947</ArticleId></ArticleIdList></Reference><Reference><Citation>Surg Clin North Am. 2010 Aug;90(4):665-77</Citation><ArticleIdList><ArticleId IdType="pubmed">20637940</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Suède</li></country></list><tree><country name="Suède"><noRegion><name sortKey="Jawad, Rim" sort="Jawad, Rim" uniqKey="Jawad R" first="Rim" last="Jawad">Rim Jawad</name></noRegion><name sortKey="Bjornstedt, Mikael" sort="Bjornstedt, Mikael" uniqKey="Bjornstedt M" first="Mikael" last="Björnstedt">Mikael Björnstedt</name><name sortKey="D Souza, Melroy" sort="D Souza, Melroy" uniqKey="D Souza M" first="Melroy" last="D'Souza">Melroy D'Souza</name><name sortKey="Danielsson, Olof" sort="Danielsson, Olof" uniqKey="Danielsson O" first="Olof" last="Danielsson">Olof Danielsson</name><name sortKey="Isaksson, Bengt" sort="Isaksson, Bengt" uniqKey="Isaksson B" first="Bengt" last="Isaksson">Bengt Isaksson</name><name sortKey="Lundgren, Marita Wallenberg" sort="Lundgren, Marita Wallenberg" uniqKey="Lundgren M" first="Marita Wallenberg" last="Lundgren">Marita Wallenberg Lundgren</name><name sortKey="Nowak, Greg" sort="Nowak, Greg" uniqKey="Nowak G" first="Greg" last="Nowak">Greg Nowak</name><name sortKey="Selenius, Lisa Arodin" sort="Selenius, Lisa Arodin" uniqKey="Selenius L" first="Lisa Arodin" last="Selenius">Lisa Arodin 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